Stereoselective Reactions. Part 31: Catalytic Asymmetric Alkylation of Achiral Lithium Enolates Using a Chiral Tetradentate Amine in the Presence of an Achiral Bidentate Amine

Catalytic asymmetric alkylation of achiral lithium enolates of 1-tetralone and cyclohexanone with reactive alkyl halides was realized by using a combination of a chiral tetradentate amine (∼0.05 equiv.) and an achiral bidentate amine (2 equiv.).