Title of article
Chiral 5-Methyl-trihydroxypyrrolidines—Preparation from 1,2-Oxazines and Glycosidase Inhibitory Properties
Author/Authors
Thierry Sifferlen، نويسنده , , Albert Defoin، نويسنده , , Jacques Streith، نويسنده , , Didier Le Nouën، نويسنده , , Céline Tarnus، نويسنده , , Isabelle Dosbaâ، نويسنده , , Marie-José Foglietti، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
8
From page
971
To page
978
Abstract
Chemical transformations of chiral 1,2-oxazines 4, 5 gave the 2,5,6-trideoxy-2,5-imino d-alditols 12b, 13b in the d-altritol and d-talitol series, respectively. Basic aldehyde epimerisation led to the d-allitol isomer 15b. Compound 12b is a potent α-l-fucosidase and α-d-galactosidase inhibitor.
Keywords
trihydroxypyrrolidines , glycosidases inhibitions
Journal title
Tetrahedron
Serial Year
2000
Journal title
Tetrahedron
Record number
1080568
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