Author/Authors :
Dirk Behnke، نويسنده , , Lothar Hennig، نويسنده , , Matthias Findeisen، نويسنده , , Peter Welzel، نويسنده , , Dietrich Müller، نويسنده , , Michael Thormann، نويسنده , , Hans-J?rg Hofmann، نويسنده ,
Abstract :
A new nucleophilic isoprenoid C5 reagent is introduced which allowed synthesis of an advanced and optically active forskolin intermediate in a very efficient way. In addition, docking experiments that are based on X-ray results indicate that there might exist forskolin analogues with improved properties as far as binding to adenylyl cyclases and synthetic accessibility are concerned.
