Cytotoxic Acylphenols from Myristica maingayi

From the cytotoxic AcOEt extract of the fruits of Myristica maingayi, a Myristicaceae, five new acylphenols (promalabaricones B and C, maingayic acids B and C, and maingayone) were isolated, together with the known malabaricones A–C. The structures were determined from spectral analysis, including mass spectrometry and 2D NMR. The cytotoxicity of the new compounds and that of malabaricones was assessed against KB cells. A biosynthetic pathway for malabaricones, via the corresponding promalabaricones as precursors, is suggested.