Title of article :
X-Ray Structure, Conformational Analysis, Enantioseparation, and Determination of Absolute Configuration of the Mitotic Kinesin Eg5 Inhibitor Monastrol
Author/Authors :
C. Oliver Kappe، نويسنده , , Oleg V Shishkin، نويسنده , , Georg Uray، نويسنده , , Petra Verdino، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2000
Abstract :
The conformational features of the mitotic kinesin Eg5 inhibitor monastrol were investigated by computational (AM1, HF/3-21G∗), X-ray diffraction, and NMR studies showing that monastrol is a conformationally highly flexible molecule. Racemic monastrol was resolved by direct enantioselective HPLC and the absolute configuration of the first eluting (S)-(+) enantiomer was established by CD spectroscopy.
Keywords :
Biginelli reactions , Enantiomeric purity , conformation , circular dichroism
Journal title :
Tetrahedron
Journal title :
Tetrahedron
