Enantioselective Synthesis of Pyranofuranone Moieties of Manoalide and Cacospongionolide B by Enzymatic and Chemical Approach

Two synthetic sequences leading to the pyranofuranone moieties of Manoalide and Cacospongionolide B in enantiomerically enriched forms are reported. The key steps involve either an enantioselective aldol condensation or an enzymatic resolution.