Title of article
C2-Symmetric Bis-Sulfoxide: Highly Diastereoselective 1,4-Addition to Stabilised Michael Acceptors
Author/Authors
Inmaculada Fernandez، نويسنده , , Cristina S. Ara?jo، نويسنده , , M.José Romero، نويسنده , , Felipe Alcudia، نويسنده , , Noureddine Khiar، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
5
From page
3749
To page
3753
Abstract
The reaction of (S,S)-bis-p-tolylsulfinylmethane with highly stabilised Michael acceptors was studied in detail. The stereochemical outcome of the reaction was shown to be under thermodynamic control. While an equimolar mixture of Michael adducts was obtained at −78°C, warming the reaction to room temperature allows the formation of a single isomer in quantitative yield.
Keywords
Diastereoselective synthesis , Michael addition , C2-symmetric bis-sulfoxides , thermodynamic control
Journal title
Tetrahedron
Serial Year
2000
Journal title
Tetrahedron
Record number
1080863
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