Title of article :
Mechanistic Studies in the Radical Induced DNA Strand Cleavage—Formation and Reactivity of the Radical Cation Intermediate
Author/Authors :
Ralf Glatthar، نويسنده , , Martin Spichty، نويسنده , , Andreas Gugger، نويسنده , , Rohit Batra، نويسنده , , Wolfgang Damm، نويسنده , , Matthias Mohr، نويسنده , , Hendrik Zipse، نويسنده , , Bernd Giese، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2000
Pages :
12
From page :
4117
To page :
4128
Abstract :
In order to understand the heterolytic cleavage of 4′-DNA radical 1 and the regioselective attack of nucleophiles at the intermediate DNA radical cation 3, the chemistry of model radical 8 was studied. It turned out that the heterolytic cleavage in water is favored over homolysis because of the effective solvation of the ions 9 and 10. The regioselectivity of the nucleophilic attack at radical cation 10 can be explained with the valence bond configuration mixing (VBCM) model.
Keywords :
Solvent effect , regioselective addition , Radical cation , 4?-DNA radical , VBCM , Calculations
Journal title :
Tetrahedron
Serial Year :
2000
Journal title :
Tetrahedron
Record number :
1080903
Link To Document :
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