Author/Authors :
Richard Freer، نويسنده , , Graham R Geen، نويسنده , , Thomas W Ramsay، نويسنده , , Andrew C Share، نويسنده , , Graham R Slater، نويسنده , , Neil C. Smith، نويسنده ,
Abstract :
An efficient route to the acyclic nucleoside analogue famciclovir has been developed based on a palladium(0) catalysed coupling of 2-amino-6-chloropurine and an allylic carbonate sidechain derived from 2,2-dimethyl-1,3-dioxan-5-one. The reaction proceeds via a highly N-9 regioselective purine allylation step involving a novel palladium mediated N-7 to N-9 rearrangement.
