Highly Efficient Synthesis of Steroidal Hydroxamic Acid Derivatives via Homogeneous Catalytic Carbonylation Reaction

Steroidal hydroxamic acid derivatives were synthesized in moderate to high yields by palladium-catalyzed carbonylation reactions of the corresponding iodo-alkenyl compounds or enol triflates in the presence of substituted hydroxylamines under mild reaction conditions. The effect of reaction parameters on the regioselectivity of carbonylation of N-substituted hydroxylamines is investigated in detail.