Title of article
Reversal of Diastereoselectivity of Nitrile Oxide 1,3-Dipolar Cycloadditions by Mg(II). Acceleration of Cycloaddition by Microwave Irradiation
Author/Authors
Peter Mi??ch، نويسنده , , Lʹubor Fi?era، نويسنده , , Michal K Cyranski، نويسنده , , Tadeusz M Krygowski، نويسنده , , J?n Kraj???k، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
8
From page
5465
To page
5472
Abstract
1,3-Dipolar cycloadditions of mesitonitrile oxide to Baylis–Hillman adducts (β-hydroxy-α-methylene esters) proceed regioselectively in good yields. Addition of Grignard reagent reverses the diastereoselectivity of the cycloaddition. Microwave irradiation strongly accelerates the reaction with only a small effect on its diastereoisomeric excess.
Keywords
Cycloaddition , Nitrile oxides , diastereoselection , Microwave heating , Isoxazolines
Journal title
Tetrahedron
Serial Year
2000
Journal title
Tetrahedron
Record number
1081042
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