Author/Authors :
Ae Nim Pae، نويسنده , , Jie Eun Lee، نويسنده , , Bo Hyung Kim، نويسنده , , Joo Hwan Cha، نويسنده , , Hea Yeon Kim، نويسنده , , Yong Seo Cho، نويسنده , , Kyung Il Choi، نويسنده , , Hun Yeong Koh، نويسنده , , Eun Lee، نويسنده , , Je Hak Kim، نويسنده ,
Abstract :
Structural modifications and biological evaluations of 3-isoxazolylvinylcephalosporins (I) were performed. The replacement of a hydrogen atom at the 7-aminothiazole group by a chlorine resulted in an improvement of the activity against resistant Gram-positive bacterial strains including the methicillin-resistant Staphylococcus aureus (MRSA) and the ciprofloxacin-resistant Staphylococcus aureus (CRSA). The introduction of other heterocycles such as an isothiazole or a thiadiazole in place of the isoxazole moiety gave slightly decreased in vitro activities.
Keywords :
Thiazoles , Cephalosporins , Antibacterials , isoxazoles
