Title of article
Ianthesines A–D, Four Novel Dibromotyrosine-Derived Metabolites from a Marine Sponge, Ianthella sp.
Author/Authors
Yoshihiro Okamoto، نويسنده , , Makoto Ojika، نويسنده , , Shigemasa Kato، نويسنده , , Youji Sakagami، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
6
From page
5813
To page
5818
Abstract
Novel dibromotyrosine-derived metabolites, ianthesines A, B, C, and D, were isolated from an Australian marine sponge of the genus Ianthella sp. Their structures were elucidated using chemical and spectroscopic techniques. Ianthesines A, B, and D were derived from two dibromotyrosines. Ianthesine C is a tetramer possessing eight bromine atoms and its molecular weight is 1606. Ianthesines B–D showed Na,K-ATPase inhibitory activity in the range of 50–440 μM, whereas ianthesine A is inactive.
Keywords
amino acids and derivatives , Enzyme inhibitors , marine metabolites , Natural products
Journal title
Tetrahedron
Serial Year
2000
Journal title
Tetrahedron
Record number
1081077
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