Title of article
Preparation of ent-Prostaglandin E2
Author/Authors
Douglass F. Taber، نويسنده , , Qin Jiang، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
5991
To page
5994
Abstract
The enantiomeric prostaglandins, exemplified by ent-PGE2, are apparently produced in vivo by the nonenzymatic oxidation of arachidonic acid. To assess the physiological activity of ent-PGE2, it was necessary to prepare it by total synthesis. The key transformation in this synthesis was the equilibration of the kinetically prepared ent-15-E2t-isoprostane to ent-PGE2.
Keywords
biologically active compounds , cyclopentanones , prostanoids , Asymmetric synthesis
Journal title
Tetrahedron
Serial Year
2000
Journal title
Tetrahedron
Record number
1081095
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