Creation of New Boron–Carbon Bonds by Dichlorocarbene Insertion into the Boron–Hydrogen Bond of Amine– and Phosphine–Boranes

A simple approach for constructing a new boron–carbon bond by direct insertion into the B–H bond of amine– and phosphine–borane complexes is described. The outcome of this reaction was studied according to the substituents and the experimental conditions. A preliminary investigation of the reactivity of some insertion products as well as their anti-proliferative activities is also reported.