Title of article
Regioselective Carbon–Carbon Bond Formation in the Effector Domain of Ascomycin
Author/Authors
Amarylla Horvath، نويسنده , , Maximilian A Grassberger، نويسنده , , Gerhard Schulz، نويسنده , , Ewald Haidl، نويسنده , , Hildegard Sperner، نويسنده , , Andrea Steck، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
8
From page
7469
To page
7476
Abstract
Starting from 33-O-silyl-protected ascomycin or its 23,24-dehydration product, regio- and stereo-selective formal aldol reactions under carbon–carbon bond formation at C-22, C-23, or C-24 are demonstrated. Additionally, with the 22-silyl enol ether ascomycin derivative a rhodium(I)-catalysed shift of the 19,20 double bond into the 19,38 exocyclic position is observed at elevated temperature.
Keywords
Aldol reaction , enol ether , ketene acetals , Regiospecificity , Macrocycles
Journal title
Tetrahedron
Serial Year
2000
Journal title
Tetrahedron
Record number
1081253
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