Author/Authors :
Hideaki Imamura، نويسنده , , Aya Shimizu، نويسنده , , Hiroki Sato، نويسنده , , Yuichi Sugimoto، نويسنده , , Shunji Sakuraba، نويسنده , , Shigeru Nakajima، نويسنده , , Shinnosuke Abe، نويسنده , , Keiko Miura، نويسنده , , Ikuko Nishimura، نويسنده , , Koji Yamada، نويسنده , , Hajime Morishima، نويسنده ,
Abstract :
An ultra-broad spectrum carbapenem, J-114,870 (1), was synthesized from the corresponding C-2 side chain and 1β-methylcarbapenem enolphosphate. Synthesis of the C-2 side chain was accomplished by installation of the benzene part to (4R)-hydroxy-2-pyrrolidone 3, affording 2-phenylpyrrolidine 8a, and asymmetric Michael addition of chiral amine to α,β-unsaturated ester derived from 8a.
Keywords :
1?-methylcarbapenem , 870 , J-114 , Asymmetric Michael addition
