Synthesis of Biaryls via Cross-Coupling Reaction of Arylboronic Acids with Aryl Chlorides Catalyzed by NiCl2/Triphenylphosphine Complexes

The cross-coupling reaction of tolylboronic acids (1.3 equiv.) with chloroarenes in toluene was carried out at 80–100°C in the presence of a NiCl2/PPh3 catalyst (3 mol%) and K3PO4·nH2O (2.6 equiv.). The reaction can be applied to various electron-deficient and -rich chloroarenes and is economical as the industrial process.