Penicillazine, a Unique Quinolone Derivative with 4H-5,6-Dihydro-1,2-oxazine Ring System from the Marine Fungus Penicillium sp. (Strain #386) from the South China Sea

Penicillazine (1) is a new compound with both quinolone and 4H-5,6-dihydro-1,2-oxazine ring systems that was isolated from a culture of the marine fungus Penicillium sp. (strain #386). Its structure was elucidated using spectroscopic methods, primarily 2D NMR techniques, and was confirmed by an X-ray diffraction analysis. Variations in the 1H NMR spectrum of penicillazine (1) were observed over a 65°C temperature range.