Author/Authors :
S.M. Abdur Rahman، نويسنده , , Hiroaki Ohno، نويسنده , , Hitoshi Yoshino، نويسنده , , Norifumi Satoh، نويسنده , , Mahoto Tsukaguchi، نويسنده , , Kazuo Murakami، نويسنده , , Chuzo Iwata، نويسنده , , Naoyoshi Maezaki، نويسنده , , Tetsuaki Tanaka، نويسنده ,
Abstract :
A model study toward the total synthesis of (±)-scopadulin is described. Stereocontrolled synthesis of the A/B ring system with desired functionalities was achieved by stereoselective cyanation of a bicyclic enone with Et2AlCN, diastereoselective construction of a quaternary carbon at C-4 with LDA-BOMCl, and conversion of the cyano group into a methyl group.
