Title of article
Synthesis and biological evaluation of deoxypreussomerin A and palmarumycin CP1 and related naphthoquinone spiroketals
Author/Authors
Peter Wipf، نويسنده , , Jae-Kyu Jung، نويسنده , , Sonia Rodr??guez، نويسنده , , John S. Lazo، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
14
From page
283
To page
296
Abstract
Oxidative cyclization of bis-hydroxynaphthyl ethers allows concise total syntheses of palmarumycin CP1 and deoxypreussomerin A in 8-9 steps and 15–35% overall yield from 5-hydroxy-8-methoxy-1-tetralone (8). Polymer-bound triphenyl phosphine was found to be a superior reagent for the rapid preparation of a small library of palmarumycin analogs. Preliminary biological evaluation of naphthoquinone spiroketals against MCF-7 and MDA-MB-231 human breast cancer cells revealed several low-micromolar growth inhibitors.
Keywords
Total synthesis , iodobenzenediacetate , Cytotoxicity , Phenol oxidation , polymer-bound reagent , spirocyclization , deoxypreussomerin , palmarumycin , Naphthoquinone , breast cancer cell line
Journal title
Tetrahedron
Serial Year
2001
Journal title
Tetrahedron
Record number
1081586
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