Title of article :
Ancorinosides B–D, inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP), from the marine sponge Penares sollasi Thiele
Author/Authors :
Masaki Fujita، نويسنده , , Yoichi Nakao، نويسنده , , Shigeki Matsunaga، نويسنده , , Motoharu Seiki، نويسنده , , Yoshifumi Itoh، نويسنده , , Rob W.M. van Soest، نويسنده , , Nobuhiro Fusetani، نويسنده ,
Abstract :
Ancorinosides B–D were isolated from the marine sponge Penares sollasi Thiele as inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP). Their structures were elucidated to be tetramic acid glycosides related to ancorinoside A by spectroscopic and chemical methods. Ancorinosides B–D inhibited MT1-MMP with IC50 values of 180–500 μg/mL.
Keywords :
marine metabolites , biologically active compounds , Sponges , Enzyme inhibitors
