Title of article
O-Ethyl 1-azidoalkylphosphonic acids—versatile reagents for the synthesis of protected phosphonamidate peptides
Author/Authors
Dorota Sikora، نويسنده , , Tomasz Nonas، نويسنده , , Tadeusz Gajda، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
7
From page
1619
To page
1625
Abstract
A new methodology for the synthesis of protected phosphonamidate peptides from O-ethyl 1-azidoalkylphosphonic acids and amino acids esters was developed. The method is general and the corresponding N-Boc protected phosphonopeptides as well as their azido analogs have been obtained in good yields. An efficient preparation of O-ethyl 1-azidoalkylphosphonic acids is also presented.
Keywords
phosphonopeptides , Amino acids , phosphonamidates , O-ethyl 1-azidoalkylphosphonic acids , diethyl 1-azidoalkylphosphonates
Journal title
Tetrahedron
Serial Year
2001
Journal title
Tetrahedron
Record number
1081727
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