Title of article
Synthesis of new bridged tetrahydro-β-carbolines and spiro-fused quinuclidines
Author/Authors
Brigitte E.A Burm، نويسنده , , Christiaan Gremmen، نويسنده , , Martin J. Wanner، نويسنده , , Gerrit-Jan Koomen، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
11
From page
2039
To page
2049
Abstract
Two series of chemically related, conformationally restricted ring systems were synthesized. Bridged tetrahydro-β-carbolines, designed as selective 5-HT receptor ligands, were formed via Pictet–Spengler condensation of cyclic tryptamine precursors. Oxidation of the indole 2-position of the precursors followed by condensation with aldehydes produced spiro-cyclic quinuclidines, containing important muscarine receptor pharmacophores.
Keywords
quinuclidines , spiro-compounds , Pictet–Spengler reaction , oxindoles
Journal title
Tetrahedron
Serial Year
2001
Journal title
Tetrahedron
Record number
1081779
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