Title of article
Synthesis of 5-alkyl-4-amino-2-(trifluoromethyl)pyridines and their transformation into trifluoromethylated 1H-pyrazolo[4,3-c]pyridines
Author/Authors
Vladimir I. Tyvorskii، نويسنده , , Denis N Bobrov، نويسنده , , Oleg G Kulinkovich، نويسنده , , Kourosch Abbaspour Tehrani، نويسنده , , Norbert De Kimpe، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
5
From page
2051
To page
2055
Abstract
5-Alkyl-4-amino-2-(trifluoromethyl)pyridines were prepared in good yields starting from the corresponding pyridinols either using condensation with tosyl isocyanate or by alkylation with 2-chloroacetamide and subsequent Smiles type rearrangement. The cyclisation of diazonium salts, generated from 5-alkyl-4-amino-2-(trifluoromethyl)pyridines, afforded trifluoromethylated 1H-pyrazolo[4,3-c]pyridines.
Keywords
4-aminopyridines , 3-c]pyridines , Smiles rearrangement , 4H-pyran-4-ones
Journal title
Tetrahedron
Serial Year
2001
Journal title
Tetrahedron
Record number
1081780
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