Author/Authors :
F.Javier Aladro، نويسنده , , Francisco M Guerra، نويسنده , , F.Javier Moreno-Dorado، نويسنده , , Jes?s M Bustamante، نويسنده , , Zacar??as D Jorge، نويسنده , , Guillermo M. Massanet، نويسنده ,
Abstract :
The enantioselective synthesis of (+)-decipienin A has been carried out. The oxidation of 7-epi-cyperone 2 with molecular oxygen in the presence of methanolic KOH provides de C-6-hydroxylated derivative in quantitative yield. The oxidation of glycols 5a through a Swern oxidation and 14a with TEMPO radical opens up a route to the synthesis of 11-hydroxy sesquiterpenolides. All attempts of oxidation of 5a or 14a with other different oxidation reagents led invariably to fragmentation products.
Keywords :
eudesmanolides , decipienin A , sesquiterpenolides , Umbelliferae , Oxidation
