Title of article
Feroxosides A-B, two norlanostane tetraglycosides from the Caribbean sponge Ectyoplasia ferox
Author/Authors
Claudio Campagnuolo، نويسنده , , Ernesto Fattorusso، نويسنده , , Orazio Taglialatela-Scafati، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
7
From page
4049
To page
4055
Abstract
Feroxosides A and B, have been isolated from the polar extract of the Caribbean sponge Ectyoplasia ferox. Their structures have been determined to be unusual C-4 nor-lanostane triterpenes glycosylated with a rhamnose containing tetrasaccharide chain, by interpretation of spectral data and chemical degradation. Absolute stereochemistry at C-23 has been determined by application of the modified Mosher method for secondary alcohols. Feroxosides A-B are moderately cytotoxic (IC50 19 μg/mL) against murine monocyte-macrophage cell line.
Keywords
terpene glycosides , NMR spectroscopy , Stereochemistry , marine metabolites
Journal title
Tetrahedron
Serial Year
2001
Journal title
Tetrahedron
Record number
1081992
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