Author/Authors :
Stefan Vogel، نويسنده , , Katherina Stembera، نويسنده , , Lothar Hennig، نويسنده , , Matthias Findeisen، نويسنده , , Sabine Giesa، نويسنده , , Peter Welzel، نويسنده , , Maxime Lampilas*، نويسنده ,
Abstract :
From moenomycin A both the chromophore part and the lipid side chain were degraded by ozonolysis to give an analogue with a glycolaldehyde unit in 2-position of the glyceric acid moiety. The aldehyde was converted to a number of homoallylic alcohols by indium-mediated Barbier-type reactions with allylic and benzylic halides. With exception of the phytyl bromide-derived reaction product all compounds were antibiotically inactive.
Keywords :
Barbier reactions , Phospholipids , Carbohydrates , Antibiotics
