Title of article
N-Methoxy-N-methyl-3-bromopropionamide: a new three carbon homologating agent for the synthesis of unsymmetrical 1,4-diketones
Author/Authors
V Selvamurugan، نويسنده , , I.S Aidhen، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
5
From page
6065
To page
6069
Abstract
A synthetic route based on a three carbon homologation of an α-aminonitrile was developed for the synthesis of unsymmetrical 1,4-diketones. The key steps were the alkylation of various aryl and heteroaryl α-aminonitriles with N-methoxy-N-methyl-3-bromopropionamide followed by the addition of a Grignard reagent to the alkylated product and then subsequent hydrolysis.
Keywords
1 , 4-diketone , Weinreb amide , homologating agent , ?-aminonitrile , Grignard reagent
Journal title
Tetrahedron
Serial Year
2001
Journal title
Tetrahedron
Record number
1082209
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