Title of article :
Spongidepsin, a new cytotoxic macrolide from Spongia sp.
Author/Authors :
Agnese Grassia، نويسنده , , Ines Bruno، نويسنده , , Cécile Debitus، نويسنده , , Stefania Marzocco، نويسنده , , Aldo Pinto، نويسنده , , Luigi Gomez-Paloma، نويسنده , , Raffaele Riccio، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2001
Abstract :
A novel macrolide, spongidepsin (1) has been isolated from the Vanuatu marine sponge Spongia sp. The structure of 1, which contains 9-hydroxy-2,4,7-trimethyltetradeca-14-ynoic acid and N-methylphenylalanine residues joined in a 13-membered ring, was elucidated by spectroscopic analysis. Spongidepsin (1) showed cytotoxic activity against J774.A1, WEHI-164 and HEK-293 cancer cell lines with an IC50 in the sub-micromolar range.
Keywords :
Cytotoxic , alkynes , macrocyclic lactone , marine metabolites
Journal title :
Tetrahedron
Journal title :
Tetrahedron
