Title of article
Facile synthesis of N-Boc-(2S,5R)-5-(1′-hydroxy-1′-methylethyl)proline
Author/Authors
Qian Wang، نويسنده , , Marie-Elise Tran Huu Dau، نويسنده , , N. André Sasaki، نويسنده , , Pierre Potier، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
8
From page
6455
To page
6462
Abstract
Coupling of chiral 1-O-benzylglycerol-2,3-bistriflate with trilithiated chiral 2-N-Boc-3-phenylsulfonylpropan-1-ol derivative constitutes an efficient route to chiral C-5 substituted prolines which can potentially induce cis Xaa-Pro peptide bond conformation. A straightforward seven-step synthesis of the title compound is described.
Keywords
cis conformer , C-5 substituted proline
Journal title
Tetrahedron
Serial Year
2001
Journal title
Tetrahedron
Record number
1082251
Link To Document