Title of article
Enantiopure Cα-tetrasubstituted α-amino acids. Chemo-enzymatic synthesis and application to turn-forming peptides
Author/Authors
Bernard Kaptein، نويسنده , , Quirinus B. Broxterman، نويسنده , , Hans E Schoemaker، نويسنده , , Floris P.J.T. Rutjes، نويسنده , , Johan J.N Veerman، نويسنده , , Johan Kamphuis، نويسنده , , Cristina Peggion، نويسنده , , Fernando Formaggio، نويسنده , , Claudio Toniolo، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
11
From page
6567
To page
6577
Abstract
By a chemo-enzymatic approach we carried out a large-scale synthesis of four enantiopure, sterically constrained, Cα-tetrasubstituted α-amino acids, all characterized by a sidechain CγCδ double bond. By using one of them (l-Mag), we prepared an Nα-protected tetrapeptide benzylamide which was shown to adopt a β-turn conformation and to efficiently undergo ring-closing olefin metathesis.
Keywords
peptides and polypeptides , amino acids and derivatives , NMR , Metathesis
Journal title
Tetrahedron
Serial Year
2001
Journal title
Tetrahedron
Record number
1082262
Link To Document