New apiose-containing triterpenoid saponins from Conyza blinii

Four new apiose-containing triterpenoid saponins, conyzasaponins D, E, F, and H, were isolated from the aerial parts of Conyza blinii. They are the first examples of triterpenoid saponins containing one apiose unit whose C-2 is substituted by a galactose. Conyzasaponins D and F have two apiose units, a sugar that has been rarely observed in natural products research. Their structures were established on the basis of extensive NMR studies and chemical degradation. Conyzasaponins D and F exhibited moderate cytotoxicity against HL-60 cell lines.