Title of article
Stereoselective reductive radical cyclization of ketonitriles catalyzed by Cp2TiCl2 in the presence of chlorosilane and zinc
Author/Authors
Longhu Zhou، نويسنده , , Toshikazu Hirao، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
7
From page
6927
To page
6933
Abstract
Reductive radical cyclization of ketonitriles was catalyzed by Cp2TiCl2 in the presence of Me3SiCl, zinc powder and imidazole, giving the 2-amino-3-cyano-2-cyclopenten-1-ols in moderate to good yields with high trans selectivity (up to 94% trans). The influence of the catalyst, chlorosilane, co-reductant, solvent, and temperature on both the yield and diastereoselectivity of the cyclized products was investigated in detail.
Keywords
titanium catalyst , diastereoselective cyclization , silylating reagent , co-reductant , one-electron reduction
Journal title
Tetrahedron
Serial Year
2001
Journal title
Tetrahedron
Record number
1082298
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