Author/Authors :
Tetsuro Ito، نويسنده , , Toshiyuki Tanaka، نويسنده , , Ken-ichi Nakaya، نويسنده , , Munekazu Iinuma، نويسنده , , Yoshikazu Takahashi، نويسنده , , Hiroshi Naganawa، نويسنده , , Masayoshi Ohyama، نويسنده , , Yuka Nakanishi، نويسنده , , Kenneth F. Bastow، نويسنده , , Kuo-Hsiung Lee، نويسنده ,
Abstract :
Vaticanol G (1) and vaticaside D (2) isolated from stem bark of Vatica rassak (Dipterocarpaceae) were the first instance of stilbenoid trimers with an unusual tribenzobicyclo[3.3.2]decatriene system. Vaticanols D (3) and H (4)–J (6) were elucidated to be a stilbenoid hexamer or heptamer containing a structurally identical trimeric unit. Their structures and the relative configurations were established on the basis of 2D NMR spectroscopy. The hexamers (3, 4 and 5) and the heptemer (6) showed cytotoxicity against KB cells.
Keywords :
Cytotoxicity , Natural product , Resveratrol , heptamer , hexamer , Dipterocarpaceae
