Title of article
A photochemical approach to phenylalanines and related compounds by alkylation of glycine
Author/Authors
Haydn S Knowles، نويسنده , , H. Keith Hunt، نويسنده , , Andrew F Parsons، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
10
From page
8115
To page
8124
Abstract
Phenylalanines can be prepared on UV photolysis of protected glycines in the presence of di-tert-butyl peroxide, substituted toluenes and the photosensitiser benzophenone. These reactions, which lead to highly selective mono-alkylation at the α-position of glycines, involve coupling of captodative α-glycine radicals with benzyl radicals. This method can be used to selectively alkylate a variety of glycine derivatives using a range of substituted toluenes under neutral reaction conditions.
Keywords
Alkylation , amino acids and derivatives , Photochemistry , radicals and radical reactions
Journal title
Tetrahedron
Serial Year
2001
Journal title
Tetrahedron
Record number
1082423
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