Assignment of the absolute stereochemistry of oxazinin-1: application of the 9-AMA shift-correlation method for β-chiral primary alcohols

Reported herein is the assignment of the absolute stereochemistry of oxazinin-1, a cytotoxic compound recently isolated from the digestive glands of Mytilus galloprovincialis of the North Adriatic Sea. The recent 9-AMA shift-correlation method for assigning absolute configuration to β-chiral primary alcohols was employed and preparatory Molecular Mechanics calculations were carried out.