Title of article
Synthesis of isoquinolines and tetrahydroisoquinolines as potential antitumour agents
Author/Authors
A.S Capilla، نويسنده , , M Romero، نويسنده , , M.D Pujol، نويسنده , , D.H Caignard، نويسنده , , P Renard، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
7
From page
8297
To page
8303
Abstract
The isoquinoline 17 and the tetrahydroisoquinoline 16 were synthesized from 2,3-dihydro-1,4-benzodioxin (1) by different synthetic strategies. Preparation of arylethylamines and their cyclization in Bischler–Napieralski conditions have been studied. Another approach to isoquinolines was based on the amination of the ketone 13 followed by cyclization in acidic media. The route via the amide 15 was found to be more successful with respect to both yield and ease of reaction.
Keywords
1-substituted isoquinoline , 1 , Cyclization , 4-benzodioxin
Journal title
Tetrahedron
Serial Year
2001
Journal title
Tetrahedron
Record number
1082444
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