Title of article
Enantioselective route to key intermediates in the synthesis of carbocyclic phosphoribosyltransferase transition state analogues
Author/Authors
Mohammad Ahmadian، نويسنده , , Naveen K. Khare، نويسنده , , James M. Riordan، نويسنده , , Anthony E. Klon، نويسنده , , Alexandre P. Kuzin and David W. Borhani، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
11
From page
9899
To page
9909
Abstract
The enantioselective preparation of key intermediates in the synthesis of transition state analogues of hypoxanthine-guanine phosphoribosyltransferase, (1S,2S,3R,4R)-4-acetoxymethyl-1-bromomethyl-2,3-isopropylidenedioxy-1-toluenesulfonamidocyclopentane (3a) and the 4-nitrobenzenesulfonamido analogue (3b), are described.
Keywords
carbocyclic nucleosides , transition state analogues , X-ray structure , HGPRT
Journal title
Tetrahedron
Serial Year
2001
Journal title
Tetrahedron
Record number
1082610
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