Enantioselective route to key intermediates in the synthesis of carbocyclic phosphoribosyltransferase transition state analogues

The enantioselective preparation of key intermediates in the synthesis of transition state analogues of hypoxanthine-guanine phosphoribosyltransferase, (1S,2S,3R,4R)-4-acetoxymethyl-1-bromomethyl-2,3-isopropylidenedioxy-1-toluenesulfonamidocyclopentane (3a) and the 4-nitrobenzenesulfonamido analogue (3b), are described.