Title of article
A total stereospecific route to α-alkylidene-γ-lactams
Author/Authors
Feten Béji، نويسنده , , Jacques Lebreton، نويسنده , , Jean Villiéras، نويسنده , , Hassen Amri، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
4
From page
9959
To page
9962
Abstract
A new efficient γ-lactams 4 synthesis was achieved by two successive reactions: alkylation of nitroalkane anions with dimethyl α-(bromomethyl) fumarate 1 leading to the formation of (E)-1-alkyl-2,3-dimethoxycarbonyl butadienes 3a,b resulting of tandem alkylation–elimination (dehydronitration) processes, followed by an intramolecular cyclization on addition of primary amine.
Keywords
dimethyl ?-(bromomethyl) fumarate , ?-Lactams , 3-dienes , 1 , Nef reaction
Journal title
Tetrahedron
Serial Year
2001
Journal title
Tetrahedron
Record number
1082617
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