Regioselective synthesis and metallation of fluoroiodopyrazines. Application to the synthesis of aryl and alkylbenzylpyrazines. Diazines. Part 31

The regioselective metallation of 2-fluoropyrazine allowed the synthesis of various 5- and 6-iodofluoropyrazines. Use of cross-coupling reactions with iodofluoropyrazines under Suzuki or Negishi conditions led to aryl and alkylfluoropyrazines. The benzylfluoropyrazines have been used as building block to synthesize a wide range of arylbenzylfluoropyrazines which could exhibit mesomorphic properties.