Title of article :
Large-scale synthesis of new cyclazines, 5-thia-1,8b-diazaacenaphthylene-3-carboxylic acid derivatives having the peripheral 12π-electron ring system
Author/Authors :
Tomomi Ikemoto، نويسنده , , Tetsuji Kawamoto، نويسنده , , Hiroki Wada، نويسنده , , Toru Ishida، نويسنده , , Tatsuya Ito، نويسنده , , Yasushi Isogami، نويسنده , , Yoshiko Miyano، نويسنده , , Yukio Mizuno، نويسنده , , Kiminori Tomimatsu، نويسنده , , Kazumasa Hamamura، نويسنده , , Muneo Takatani، نويسنده , , Mitsuhiro Wakimasu، نويسنده ,
Abstract :
The 5-thia-1,8b-diazaacenaphthylenes ( and its ester, ) are new cyclazines, in which a paramagnetic ring is present in the peripheral 12π-electron ring system. Three convenient methods of preparing have been developed. One involved thioglycolation of a new compound, 5-fluoroimidazo[1,2-a]pyridine (), followed by the Duff reaction gave in 64% yield without chromatographic purification.
Keywords :
12?-electron ring system , 5-thia-1 , 8b-diazaacenaphthylene , 2-a]pyridine , cyclazine , Duff reaction
