Title of article
Cytotoxicity and actin-depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and its analogs
Author/Authors
Hideo Kigoshi، نويسنده , , Kiyotake Suenaga، نويسنده , , Masaki Takagi، نويسنده , , Atsushi Akao، نويسنده , , Kengo Kanematsu، نويسنده , , Noriyuki Kamei، نويسنده , , Youko Okugawa، نويسنده , , Kiyoyuki Yamada، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
28
From page
1075
To page
1102
Abstract
Artificial analogs of aplyronine A (), a potent antitumor macrolide, were synthesized and structure–activity (cytotoxicity and actin-depolymerizing activity) relationships were investigated; the side-chain in was found to play a key role in both biological activities.
Keywords
marine metabolites , Analogs , Synthesis , structure–activity , actin-depolymerizing , cytotoxicty
Journal title
Tetrahedron
Serial Year
2002
Journal title
Tetrahedron
Record number
1082779
Link To Document