Title of article
Solid-phase parallel synthesis of 2-aminoimidazolidin-4-ones
Author/Authors
Yongping Yu، نويسنده , , John M. Ostresh، نويسنده , , Richard A. Houghten، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
5
From page
3349
To page
3353
Abstract
The solid phase synthesis of 2-aminoimidazolidin-4-ones from resin-bound amino acids is described. Resin-bound thioureas were treated with Mukaiyamaʹs reagent (2-chloro-1-methypyridinium iodide) to form, via intramolecular cyclization, resin-bound 2-iminoimidazolidin-4-ones. Following alkylation and cleavage, the corresponding 1,5-disubstituted 2-aminoimidazolidin-4-ones were provided in good yield and purity.
Keywords
Solid phase , 2-aminoimidazolidin-4-ones , Organic synthesis
Journal title
Tetrahedron
Serial Year
2002
Journal title
Tetrahedron
Record number
1083011
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