Solid-phase parallel synthesis of 2-aminoimidazolidin-4-ones

The solid phase synthesis of 2-aminoimidazolidin-4-ones from resin-bound amino acids is described. Resin-bound thioureas were treated with Mukaiyamaʹs reagent (2-chloro-1-methypyridinium iodide) to form, via intramolecular cyclization, resin-bound 2-iminoimidazolidin-4-ones. Following alkylation and cleavage, the corresponding 1,5-disubstituted 2-aminoimidazolidin-4-ones were provided in good yield and purity.