Title of article
Synthesis of 5-deazathiogirollines: analogs of a natural antitumor agent
Author/Authors
Bruno Schiavi، نويسنده , , Alain Ahond، نويسنده , , Ali Al Mourabit، نويسنده , , Christiane Poupat، نويسنده , , Angèle Chiaroni، نويسنده , , Christiane Gaspard، نويسنده , , Pierre Potier، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
15
From page
4201
To page
4215
Abstract
2-Aminothiazole analogs of the natural antitumor agent, girolline, were prepared in natural stereochemistry series (threo) and in a non-natural series (erythro). The key-step involved a coupling reaction between 2,3-O-isopropylidene-d-glyceraldehyde and a properly protected 2-aminothiazole, via a dianion species. The biological activity of the prepared analogs was evaluated on human cancer cells to determine structure–activity relationship.
Keywords
aminothiazole , antitumor compounds , marine metabolite , structure–activity
Journal title
Tetrahedron
Serial Year
2002
Journal title
Tetrahedron
Record number
1083106
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