Novel cytotoxic acylphenol dimers of Myristica gigantea; enzymatic synthesis of giganteones A and B

Three new compounds, prepromalabaricone B () and two dimeric acylphenols, giganteones A () and B () were isolated from EtOAc extract of the fruits of Myristica gigantea (Myristicaceae), together with known promalabaricone C (), malabaricones A–C () and maingayone (). The structures were determined by mass and 2D NMR spectral analysis, and the enzymatic synthesis of giganteones A and B was performed from malabaricone C. Both and possess significant cytotoxic activity in vitro against human nasopharynx KB cells.