Author/Authors :
Bryan Miller، نويسنده , , Joseph G Stowell، نويسنده , , Sundeep Dugar، نويسنده , , Thomas E Moock، نويسنده , , Christopher W Jenks، نويسنده , , Steven C Farmer، نويسنده , , Bach Phan، نويسنده , , Chad E. Wujcik، نويسنده , , Marilyn M Olmstead، نويسنده ,
Abstract :
Diazotization of 7-amino-5,8-dimethyl-6-(phenylthio)isoquinoline unexpectedly led to the formation of a new ring system, 3H-pyrazolo[3,4-h]isoquinoline as its 5-methyl-6-phenylthio derivative. In this work, the parent ring system was synthesized and characterized, along with its 5-methyl, 6-bromo-5-methyl, and 5-methyl-6-phenylthio derivatives. The mechanism for the transformation is explored.
Keywords :
isoquinolines , diazo compounds , Cyclisation , indazoles
