Author/Authors :
Tomihisa Ohta، نويسنده , , Takuro Maruyama، نويسنده , , Minoru Nagahashi، نويسنده , , Yasuyo Miyamoto، نويسنده , , Shinzo Hosoi، نويسنده , , Fumiyuki Kiuchi، نويسنده , , Yasushi Yamazoe، نويسنده , , Sachiko Tsukamoto، نويسنده ,
Abstract :
A new furanocoumarin derivative, paradisin C, was isolated from grapefruit juice as an inhibitor of cytochrome P450 (CYP) 3A4. Its stereochemistry was elucidated by spectroscopic methods. The stereochemistries of 17,18-dihydroxybergamottin and 17-epoxybergamottin were also elucidated.
Keywords :
grapefruit juice , furanocoumarin , CYP3A4 inhibition , absolute stereochemistry , paradisin
