Title of article
Ring opening reactions of 2-methyleneoxetanes
Author/Authors
Ying Wang، نويسنده , , Henri Bekolo، نويسنده , , Amy R. Howell، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
7
From page
7101
To page
7107
Abstract
Ring opening of 2-methyleneoxetanes with stabilized carbanion nucleophiles provides substituted ketones. The intermediate enolate can be trapped as its silylenol ether. If the 2-methyleneoxetane is exposed to more strongly basic carbanions, the corresponding homopropargylic alcohol is isolated in excellent yield. A variety of heteroatom nucleophiles also open the 2-methyleneoxetane in good to excellent yields.
Keywords
Ring opening , 2-methyleneoxetane , Nucleophiles , homopropargyl alcohol
Journal title
Tetrahedron
Serial Year
2002
Journal title
Tetrahedron
Record number
1083411
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