Title of article
Practical enantioselective synthesis of a COX-2 specific inhibitor
Author/Authors
Lushi Tan، نويسنده , , Cheng-yi Chen، نويسنده , , Weirong Chen، نويسنده , , Lisa Frey، نويسنده , , Anthony W. King، نويسنده , , Richard D Tillyer، نويسنده , , Feng Xu، نويسنده , , Dalian Zhao، نويسنده , , Edward J.J Grabowski، نويسنده , , Paul J Reider، نويسنده , , Paul OʹShea، نويسنده , , Philippe Dagneau، نويسنده , , Xin Wang، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
8
From page
7403
To page
7410
Abstract
Two synthetic strategies to the COX-2 specific inhibitor have been described that allowed its preparation in large quantities in 79% overall yield from (S)-2-hydroxy-2-methylbutyric acid. These studies have led to the identification of an efficient resolution of (±)-2-hydroxy-2-methylbutyric acid and a novel thionyl chloride aided formation of amide from acid .
Keywords
COX-2 inhibitor , Resolution , Suzuki coupling , hydroxy ketone
Journal title
Tetrahedron
Serial Year
2002
Journal title
Tetrahedron
Record number
1083444
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